Smithkline Beecham Corporation

Other

Kalypsys, Inc.

Russell Donovan Cousins

John Duncan Elliott

Jack Dale Leber

Maria Amparo Lago

Catherine Elizabeth Peishoff

William Henry Miller

Richard McCulloch Keenan

Irene Nijole Uzinskas

Chet Kwon

John G Gleason

James Francis Callahan

Ralph F Hall

Stewart Alwyn Noble

James S Frazee

Mark R Herbert

John D Elliott

Hengyuan Lang

Timothy Gahman

Christian Andreus Hassig

Christopher R Santos

Xiaohong Chen

Angelina M Thayer

Hui Zhuang

The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently selected from the group consisting of CR, N, NR, S, and O; U is selected from the group consisting of CRand N; V is selected from the group consisting of CRand N; W and W' are independently selected from the group consisting of CH, CRR, NR, O, N(O), S(O)and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.

Inducible nitric oxide synthase dimerization inhibitors

Compounds having a benzodiazepinyl core structure are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis, angiogenesis, tumor growth and metastasis, atherosclerosis, restenosis and inflammation.

Vitronectin receptor antagonists

Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis.

Novel indane and indene derivatives are described which are endothelin receptor antagonists.

Endothelin receptor antagonists

Indane and indene compounds are described which are endothelin receptor antagonists.

Endothelin receptor anatagonists

This invention covers quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids leukotriene inhibitors having the following general formula ##STR1## where the substituents are defined herein.

Quinolinyl substituted phenyl/thioalkanoic acid substituted propionic

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Oxford, PA, United States of America

Russell Donovan Cousins