Sanford-burnham Medical Research Institute

Rosalind Franklin University of Medicine and Science

Sanford Burnham Prebys Medical Discovery Institute

Russell Dahl

Nicholas D P Cosford

Anthony B Pinkerton

Jose Luis Millan

Grace E Stutzmann

Christopher H Kaiho

Douglas J Sheffler

Raveendra Panickar Dhanya

Nicholas DP Cosford

Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Sulfonamide compounds and uses as TNAP inhibitors

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof

Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.

Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

Disclosed herein are methods and compositions comprising compounds of formula (I) capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.

Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

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La Jolla, CA, United States of America

Russell Dahl