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C. L. Instruments Limited

Russell C Scaduto, Jr

William R Moyle

A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample () comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent has a net charge different from the analyte; (b) a first permeable polymeric hydrogel plate () and a first spacer plate (), which plates provide a compartment for the sample; (c) an anode () juxtaposed to the outside of the first hydrogel plate and not in contact with the sample; (d) a cathode () juxtaposed to the outside of the first spacer plate and not in contact with the sample; (e) a voltage generator () to apply an electric potential to the anode and cathode; and (f) a detector (). The bound complex formed from the analyte and detection reagent is detected by the detector because the bound complex has a charge that causes it to migrate in a direction opposite from that of the unbound analyte when the electric potential is applied.

Sensors for biomolecular detection and cell classification

A chamber is provided having a main body and one or two optical plates that are held to the main body by O-rings or other seal forming elements using forces created by vacuum and/or chemical adhesion. The chamber, in which a sample well holds a specimen, is formed from the optical elements that function as observation windows, being held to the main body from one side only by the seal forming elements.

Growing community of inventors

Hummelstown, PA, United States of America

Russell C Scaduto, Jr