Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a.

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Institute of Pharmacology and Toxicology Academy of Military Science P.l.a. China

Rusheng Zhao

Liuhong Yun

Rifang Yang

Jin Li

Hui Zhu

Rui Song

Ning Wu

Ruibin Su

Wei Liu

Hai Feng Wang

Peng Li

Lin Wang

Cheng Zhang

Gang Hu

Lijun Liu

Nan Zhao

Yunfeng Li

Rui Xue

Hongxia Chen

Yuan Yan

Youzhi Zhang

Yongzhen Li

Juanjuan Qin

Li Yuan

Zhenzhen Wang

Fulin Li

Qixiu Gao

Wenyu Cui

Chaoliang Long

Xinqiang Lu

Zengliang Jin

Xiaodan Xu

Jiazhi Yao

Huasong Feng

Xingchun Tang

Huamei He

Hai Wang

Zengling Jin

The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction. 

Dopamine D3 receptor ligands and preparation and medical uses of the same

Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof.  The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.

1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof

The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression. 

Amine derivative with potassium channel regulatory function, its preparation and use

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Beijing, China

Rusheng Zhao