Amgen Research (munich) Gmbh

Amgen Research Gmbh

Ruprecht Zierz

Peter Kufer

Tobias Raum

Patrick Hoffmann

Doris Rau

Ralf Lutterbüse

Claudia Blümel

Christoph Dahlhoff

Bertram Weiss

Jonas Anlahr

Lisa Nahrwold

Anna-Lena Frisk

Ann-Lena Frisk

Ralf LUTTERBÜSE

Claudia BLÜMEL

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Bispecific antibody constructs for CDH3 and CD3

The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

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Berlin, Germany

Ruprecht Zierz