William Marsh Rice University

Ruofan Li

Kyriacos Costa Nicolaou

Te-ik Sohn

Emmanouil N Pitsinos

Zhaoyong Lu

James Woods

In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.

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Houston, TX, United States of America

Ruofan Li