Amazentis Sa

Rune A Ringom

Christopher Rinsch

The invention provides compounds of formula (I) or salts thereof: The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.

Prodrugs of urolithins and uses thereof

The invention provides compounds of formula (I) or salts thereof:  The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.

The invention provides compounds of formula (I) or salts thereof: wherein:A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR; each Rbeing independently H or C(&#x2550;O)R, and at least one Rgroup being C(&#x2550;O)R; where each Ris selected from:CHRNHR, where Ris H and Ris a group selected from CH, CHCH(CH), CH(CH)CHCH, CHPh, CH-3-(1H-indole), CHCHSCH, CHOH, CHOHCH, CHSH, CHSeH and CHPhpOH,wherein said Rgroup can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORor C-Calkyl;or Rand Rtogether with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORor C-Calkyl,wherein Ris C-Calkyl optionally substituted with one or more halogen, cyano or nitro groups. The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.

Growing community of inventors

Uppsala, Switzerland

Rune A Ringom