Connaught Laboratories Limited

Sanofi Pasteur Inc.

Aventis Pasteur Limited

Sanifo Pasteur Limited

Run-Pan Du

Michel Henri Klein

Mary E Ewasyshyn

Sheena M Loosmore

Yan-Ping Yang

Anthony Bernard Schryvers

Robin E Harkness

Lisa E Myers

Quijun Wang

Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.

Chimeric immunogens

Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins ofstrains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain offree of other proteins of thestrain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.

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Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

Transferrin receptor genes of Moraxella

Transferrin receptor of moraxella

Multimeric hybrid gene encoding a chimeric protein which confers protection against parainfluenza virus and respiratory synctial virus

Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as,, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 and ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

Lactoferrin receptor genes of Moraxella

Infection detection method using chimeric protein

Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

DNA encoding a transferrin receptor of Moraxella

Chimeric protein which confers protection against parainfluenza virus

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Thornhill, Canada

Run-Pan Du