Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Academy of Military Medical Sciences

Ruiyuan Cao

Song Li

Wu Zhong

Junhai Xiao

Xinbo Zhou

Xingzhou Li

Zhibing Zheng

Lili Wang

Wei Li

Ningshao Xia

Lei Zhao

Yunde Xie

Xiaokui Wang

Yanming Wang

Qi Sun

Hongliang Wang

Long Long

Feifei Li

Cheng Cao

Shuang Cao

Dian Xiao

Ting Gao

Gengfu Xiao

Zhihong Hu

Manli Wang

Leike Zhang

Libao Xu

Fangyuan Cao

Haoming Luo

Shiyong Fan

Yuexiang Li

Tong Cheng

The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease

Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker

The present application relates to a Favipiravir compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for treating a coronavirus infection. 

Use of Favipiravir in treatment of coronavirus infection

The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection. 

4-oxo-4,5-dihydrothiazole derivative, preparation method and use thereof

The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-&#x3b1;, particularly HIF-1&#x3b1;, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury. 

Substituted acethydrazide derivative, preparation method and use thereof

The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method, pharmaceutical composition and use thereof. The compounds of the present invention overcome the defects of rapamycin in terms of water solubility and metabolic properties, and some of the compounds have an in vitro anti-tumor activity superior to rapamycin, have less toxicity to normal cells than rapamycin, and have very good druggability. 

Rapamycin derivative, and a preparation method, pharmaceutical composition and use thereof

The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium 

N-sulfonyl homoserine lactone derivatives, preparation method and use thereof

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Beijing, China

Ruiyuan Cao