Pharmacopeia Drug Discovery, Inc.

Pharmacopeia Inc.

Schering Corporation

Scheeing Corporation

Ruiyan Liu

Neng-Yang Shih

Robert G Aslanian

Kevin D McCormick

Younong Yu

Christopher W Boyce

Pietro Mangiaracina

Manuel De Lera Ruiz

Vinh D Tran

Chia-Yu Huang

Bo Liang

Rong-qiang Liu

Lisa Guise-Zawacki

Vu Van Ma

Roland Ellwood Dolle

Koc-Kan Ho

Tao Guo

Vidyadhar Madhav Paradkar

Purakkattle J Biju

Edward McDonald

Kurt William Saionz

Junying Zheng

Ray Anthony James

Guizhen Dong

Michelle Lee Morris

Salem Fevrier

Steven G Kultgen

Rui Zhang

Chongwu Zhang

Michael J Ohlmeyer

Anton Egbert Peter Adang

Peng Geng

Nicole Corine Renee Van Straten

James Robert Merritt

Jinqi Liu

Marc Brescia

Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation

In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as &#x3b1;2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the &#x3b1;2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.

ALPHA2C adrenoreceptor agonists

&#x3b1;2C adrenoreceptor agonists

The invention relates to bisaryl derivatives of the formula I,wherein (R,R) is selected from (H,H), O, (H,CH), (H,OH) and (H,CN); Ar is substituted phenyland A is a group of formula II, III, IV or V: An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimethoxyphenyl)benzyl)-4-N-methyl-6-methyl-2,5-dioxo-1,4-piperazine: The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.

Bisaryl derivatives having FSH modulatory activity

Photocleavable and acid cleavable linkers for combinatorial chemistry

A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R,is &mdash;NO,or &mdash;CHO; R,is &mdash;OCH,, &mdash;CHO or &mdash;H; R,is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n&equals;1 or 3.

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Yardley, PA, United States of America

Ruiyan Liu