Jilin University

Ruisong Xue

Wensheng Yang

Yanmei Liu

Shiyong Teng

Jinshuo Li

Xiaoyu Geng

Zhenzhen Huang

The present disclosure provides use of guar gum, a fluorescence-enhanced gold nanocluster, a method for detecting α-glucosidase (α-Glu), and a method for screening an α-Glu inhibitor, and belongs to the technical field of nanoscale biosensing. The present disclosure provides the use of the guar gum in improving a fluorescence emission intensity of a gold nanocluster. In the present disclosure, the guar gum is a natural high-molecular polymer extracted from seeds of guar, a leguminous plant, and has a low price, no toxicity, and desirable biocompatibility. The guar gum includes galactose and mannose, is rich in hydroxyl groups in a molecular backbone, and can improve a fluorescence emission intensity of the gold nanocluster. On this basis, detection of an α-Glu activity and screening of an α-Glu inhibitor can be realized with a high sensitivity and low cost.

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Changchun, China

Ruisong Xue