Memory Pharmaceuticals Corporation

3-dimensional Pharmaceuticals, Inc.

Ruiping Liu

Allen T Hopper

Ashok Tehim

Hans-Jurgen E Hess

Erik Mikal Kuester

Richard A Schumacher

Robert F Dunn

William F Brubaker

Michael De Vivo

Yajing Rong

Axel Unterbeck

Richard M Soll

Sanath K Meegalla

Daljit Singh Dhanoa

Gary M Silver

Deyou Sha

Richard Conticello

Dario Doller

Thomas E Renau

Hans-Jürgen Ernst Hess

Hans-J&uuml;rgen Ernst Hess

Yu-Kai Lee

Mark Phillip Arrington

Mike De Vivo

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein.

Phosphodiesterase 4 inhibitors

Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., pyschoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.

Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors

PDE4 inhibition is achieved by novel compounds of the Formula I: wherein Rand Rare as defined herein.

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I:wherein R, R, and Rare as defined herein.

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R, R, Rand Rare as defined herein.

Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides

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Huntington, NY, United States of America

Ruiping Liu