The United States of America, As Represented by the Secretary, Department of Health and Human Services

Florida State University Research Foundation, Inc.

University of Pennsylvania

New York University

Johns Hopkins University

Health Research, Inc.

Ruili Huang

Wenwei Huang

Wei Ping Zheng

Hengli Tang

Hongjun Song

Miao Xu

Emily M Lee

Khalida Shamim

Guoli Ming

Dan R Littman

Jun R Huh

Erika Elaine Englund

Guo-Li Ming

Hao Li

Shu Yang

Anil Mathew Tharappel

Menghang Xia

Laura D Kramer

Zhong Li

Hongmin Li

Zhexing Wen

Xin-zhuan Su

Jing Yuan

Dipak Raj

Sittiporn Pattaradilokrat

Ron Johnson

Yichen Cheng

Yi Zhou

The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

Method for inhibiting dengue virus infection

Method for inhibiting Zika virus infection

Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus.

Pharmaceutical compositions with antiflaviviral activity

Anti-flavivirus compounds and methods of use

The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as dengue virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as dengue virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such dengue virus infections.

Emetine compounds for treatment and prevention of flavivirus infection

The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

Compounds and methods for treatment and prevention of Flavivirus infection

Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R, R, R, R, R, R, and Rare as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Amido compounds as ROR&#x3b3;t modulators and uses thereof

The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

Amido compounds are disclosed that have a formula represented by the following: and wherein Cy, Cy, n1, n2, R, R, R, R, R, R, and Rare as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

The invention provides methods and compounds for the treatment and prevention of malaria infection and transmission in a mammal by administering compounds of the invention to a mammal having or suspected of having a malaria infection. The invention also provides pharmaceutical compositions that can kill or arrest the growth oforganisms, and especially, thereby preventing or blocking transmission of malaria as well as treating malaria infection.

Compounds that treat malaria and prevent malaria transmission

Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR&#x3b3;t modulators that have a formula represented by the following: and wherein n1, n2, R, R, R, and Rare as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Compounds as ROR&#x3b3;t modulators and uses thereof

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Rockville, MD, United States of America

Ruili Huang