The Kitasato Institute

Merck + Co., Inc.

Kyowa Hakko Kogyo Kabushiki Kaisha

Ruiko Oiwa

Satoshi Omura

Sheldon B Zimmerman

Juichi Awaya

Ray S Dewey

Akira Nakagawa

Yuzuru Iwai

Patrick J Cassidy

James E Flor

Hiroshi Hashimoto

Haruo Tanaka

Kanki Komiyama

Yasuhiko Kojima

Iwao Umezawa

Yoko Takahashi

Atsushi Hirano

Keiki Satoh

Vincent P Gulla

Chiaki Kitao

A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C.sub.19 H.sub.26 NO.sub.3 Cl, and having the following physicochemical properties:

Antiviral antibiotic substance AM-2722 and process for production thereof

There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.

Process for producing A73A, a new Efrotomycin-like antibiotic in

There is disclosed a new antibiotic agent, A40A, produced by Streptomyces lavedulae MA-4758 (ATCC 31312) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.

A40A Efrotomycin-like antibiotic in fermentation broth

Discovery of A73A, a new efrotomycin-like antibiotic in fermentation

The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.

Antibiotic composition

A novel compound frenolicin B of the formula: ##STR1## is prepared by cultivating a microorganism belonging to genus Streptomyces, e.g. Streptomyces roseofulvus AM-3867, in a culture medium and isolating the compound formed and accumulated in the medium from the cultured product. Said frenolicin B is useful as an antibiotic.

Compound, frenolicin B which is useful as an antibiotic

The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.

Antibiotic OS-3256-B

Growing community of inventors

Yokohama, Japan

Ruiko Oiwa