Chinese Pla General Hospital

Ruijun Li

Wei Li

Xin Li

Lili Wang

Song Li

Wu Zhong

Junhai Xiao

Zhibing Zheng

Juan Liu

Long Long

Chunlei Liu

Guoliang Hu

Jie Tang

Jie Wang

Hua Chen

Kunlun He

Jie Bai

Kunluu He

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis. 

Acrylamide compounds and use thereof for inhibiting apoptosis

A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis. 

Urea compounds and use thereof for inhibiting apoptosis

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Beijing, China

Ruijun Li