Depuy Synthes Products, Inc.

Ruijiao Xu

Lacey Gorochow

Daniel Solaun

David Blumenstyk

Juan A Lorenzo

Shawn Kallivayalil

Yusuf Sevencan

Disclosed herein are various exemplary systems, devices, and methods for inhibiting premature implant deployment. The delivery member can include a body including a lumen extending therethrough, the body including a compressed distal portion. The delivery member can include a pull wire extending through the lumen. The pull wire can include a pull wire portion that extends radially to abut a sidewall of the body to provide frictional resistance against the body. The pull wire can be positioned to secure the implantable medical device to the delivery member, and the pull wire portion can be effective to inhibit premature detachment of the implant by inhibiting proximal translation of the pull wire due to the frictional resistance provided by the pull wire portion against the body.

Systems and methods for inhibiting premature embolic implant deployment

An example aneurysm implant can include a tubular braid that can have an open end, a pinched end, and a predetermined shape. In the predetermined shape, the tubular braid can have three segments and two inversions, one of the three segments extending between the two inversions and forming a sack. Two of the segments can form a substantially semispherical shape. The tubular braid can be implanted in an implanted shape based on the predetermined shape. The substantially semispherical shape of the tubular braid can aid in decreasing a pulsatile blood inflow rate and a pulsatile blood outflow rate for a substantially spherical aneurysm cavity.

Semispherical braided aneurysm treatment system and method

An implant can be implanted in an aneurysm to cause thrombogenesis within the aneurysm's sac. The implant can include a braid that can extend across the aneurysm neck and anchor to aneurysm's walls at least in the proximal portion of the aneurysm sac. The implant can further include a dome feature configured to press into aneurysm walls near the aneurysm's dome and facilitate securement of the braid across the aneurysm's neck. The braid at the aneurysm's neck and the dome feature can be joined or constricted at a junction, for instance with a radiopaque band. The dome feature can include a braid, embolic coil, and/or wire frame. The braid can be inverted based on a heat-set predetermined shape, where several predetermined shapes are suitable.

Inverting braided aneurysm implant with dome feature

Disclosed herein are various exemplary systems and methods for deploying an implant to a target location of a body vessel. The delivery member can include a tubular body including a lumen and compressed distal portion. The delivery member can include a loop wire with a loop opening positioned approximate the compressed distal portion. The delivery member can include a pull wire that has a proximal pull wire portion and a distal pull wire portion connected by a suture linkage. The suture linkage can include a proximal suture knot engaged to the proximal pull wire portion and a distal suture knot engaged to the distal pull wire portion. Pull wire beads positioned on the proximal pull wire and distal pull wire portion can retain the suture knots during proximal translation of the pull wire. The suture linkage can include slack that is effective to prevent premature deployment of the implant.

Suture linkage for inhibiting premature embolic implant deployment

The present invention provides a braided implant with a retractable dual proximal layer and methods for administering the braided implant to treat aneurysms. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can also have a retractable ball segment at the proximal end of the device made of the same braid that can be heat treated into an ellipsoid shape. The retractable ball segment can be movable from a position outside the aneurysm to a position at least partially enclosed within the implant to increase or decrease the height of the implant relative to the aneurysm or better conform the implant to the neck of the aneurysm.

Aneurysm treatment with pushable ball segment

A tubular braided implant is provided including a braid that can be delivered as a single layer braid, invert into itself during deployment to form at least two nested sacks and include additional braid material that can fill the innermost sack. The additional braid material can loop or coil like a ribbon and/or invert to form smaller and smaller nested sacks. The braid can have a variable braid angle along its length such that when positioned for delivery, the can have a high braid angle near its distal end and a low braid angle near the proximal end. In addition, or as a replacement for the braid material that fills the innermost sack, the implant can include an embolic coil that can loop within the innermost sack.

Intrasaccular inverting braid with highly flexible fill material

The present disclosure relates to a braid for treating an aneurysm. The braid can include a proximal expandable portion for positioning inside the aneurysm and sealing across a neck of the aneurysm. The braid can also include a distal expandable portion distal of the proximal expandable portion, the distal expandable portion for filling the aneurysm.

Aneurysm device and delivery system

The present invention provides a braided implant with a retractable dual proximal layer and methods for administering the braided implant to treat aneurysms. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can also have a retractable dual layer at the proximal end of the device made of the same braid to provide additional coverage at the neck of the aneurysm. The dual layer can be pressed distally into a first implanted portion of the tubular braid, moving the first portion of the tubular braid towards the distal portion of an aneurysm wall so that the implant can partially or completely occlude an aneurysm neck.

Aneurysm treatment with pushable implanted braid

An example implant can have a tubular braid. The tubular braid can have an intrasaccular section, an intravascular section, a pinched section, and a predetermined shape. In the predetermined shape, the intrasaccular section can have a sack and an opening. The pinched section can be positioned approximate the opening. The intravascular section can be substantially disk shaped and positioned to occlude the opening. The tubular braid can be movable from a collapsed shape sized to traverse a catheter to an implanted shape based at least in part on the predetermined shape. In the implanted shape, the intrasaccular section of the braid can be sized to be positioned within an aneurysm's sac and the intravascular section of the braid can be sized to appose a blood vessel wall approximate an aneurysm's neck.

Implant having an intrasaccular section and intravascular section

An implant having two layers of tubular braid is provided that can secure within an aneurysm sac, occlude a majority of the aneurysm's neck, and at least partially fill the aneurysm sac. The implant can include two layers of tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position. In some examples, the two layers can be implanted in two distinct implanted shapes, allowing for treatment of a wide range of aneurysm sizes. In some examples, the implanted can include a double layer braided compaction resistant column spanning the height of the aneurysm.

Layered braided aneurysm treatment device

An example system can include a tubular braid, a catheter, and an embolic coil. The tubular braid can have an open end, a pinched end, and a predetermined shape. In the predetermined shape, the tubular braid can have two inversions and a middle segment extending between the two inversions that forms a sack. The tubular braid can be implanted in an implanted shape based on the predetermined shape. A distal end of the catheter can be inserted into the sack when the tubular braid is implanted. The embolic coil can be delivered through the catheter into the sack. The opening to the sack can correspond to a constricted columnar segment of the middle segment when the braid is in the predetermined shape.

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Raynham, MA, United States of America

Ruijiao Xu