The Rockefeller University

Ruijiang Song

David D Ho

Yaoxing Huang

David Joon Ho

Craig Stuart Pace

Qing Fang

Disclosed herein are glycan-modified anti-CD4 monoclonal antibodies with N-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for HIV prevention and therapy are also disclosed.

Glycan-modified anti-CD4 antibodies for HIV prevention and therapy

Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity

Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.

Fusion antibodies for HIV therapy

Growing community of inventors

Rego Park, NY, United States of America

Ruijiang Song