Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Institute of Pharmacology and Toxicology Academy of Military Science P.l.a. China

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Ruibin Su

Jin Li

Hui Zhu

Liuhong Yun

Rifang Yang

Rui Song

Ning Wu

Rusheng Zhao

The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction. 

Dopamine D3 receptor ligands and preparation and medical uses of the same

The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.

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Beijing, China

Ruibin Su