Shenyang Pharmaceutical University

Northeastern University

Rui Wang

Dan Liu

Qiuye Sun

Dazhong Ma

Linxiang Zhao

Yongkui Jing

Jingli Wang

Zhenjun Bian

Jinling Lv

Zhenao Sun

The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately. 

2-methylene-5-substituted-methylenecyclopentanone derivatives and use thereof

The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I, including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as active ingredient; uses in the preparation of vascular endothelial growth factor receptor tyrosine kinase inhibitors, and uses in the preparation of medicament for the treatment and/or prevention of cancer. 

Aromatic ring fused triazine derivatives and uses thereof

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Shenyang, China

Rui Wang