Shenzhen Turier Biotech Co. Ltd.

Guangzhou Imd Therapeutics Co., Ltd.

Rui Wang

Yong Xu

Yan Zhang

Xiaoqian Xue

Xianxing Jiang

Xiaoyu Luo

Xishan Wu

Yudan Shi

Provided are a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided are a pharmaceutically acceptable salt, isomer, racemate, prodrug co-crystal complex, hydrate, and solvate of the compound, as well as an application thereof in the preparation of a drug for the treatment or prevention of RORγ-regulated diseases; more importantly, such a compound can also be used in the preparation of a drug for the treatment of inflammation, immune diseases, cancer and neurological diseases.

Benzidine compound and application thereof

The invention relates to uses of polypeptide compounds having dual target agonist effect on glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). Characterized by high enzymolysis stability, high biological activity and no adverse reaction, the polypeptide compounds are capable of reducing abnormal increase of triglycerides and total cholesterol in blood induced by diabetes mellitus and high fat diet, reducing liver enzyme level, reducing liver injury and fibrosis stage, and preventing or treating non-alcoholic fatty liver diseases (NAFLDs), hyperlipemia and arteriosclerosis.

GLP-1R/GCGR dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis

Growing community of inventors

Guangzhou, China

Rui Wang