Flodesign Sonics, Inc.

Kedar C. Chitale

Jr., Walter M. Presz

Bart Lipkens

Benjamin Ross-Johnsrud

Rui Tostoes

Jack Saloio

Walter M Presz, Jr

Kedar C Chitale

Rudolf Gilmanshin

Jason Dionne

Brian Dutra

Goutam Ghoshal

Natalia Rodionova

Ruan Zhang

Krishna N Kumar

Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.

Acoustic cell separation techniques and processes

Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

Expanded bed affinity selection

A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

Cell therapy processes utilizing acoustophoresis

Growing community of inventors

Northampton, MA, United States of America

Rui Tostoes