The United States of America, As Represented by the Secretary, Department of Health and Human Services

Rui-Ping Xiao

Irving William Wainer

Weizhong Zhu

Khalid Chakir

Darrell R Abernethy

Farideh M Beigi Abhari

Edward G Lakatta

Li Lin

Wen Wei

Mark I Talan

Sungha Park

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding &#x3b2;2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding &#x3b2;2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

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The present disclosure provides a method for recombinant production of human sRAGE in mammalian cells, as well as a human sRAGE having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human sRAGE having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal.

Human soluble receptor for advanced glycation end products (sRAGE), methods of preparing human sRAGE, and treatment methods using sRAGE

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Baltimore, MD, United States of America

Rui-Ping Xiao