Universidade Do Minho

Association for the Advancement of Tissue Engineering and Cell Based Technologies & Therapies (a4tec) - Associacão

Association for the Advancement of Tissue Engineering Cell Based Technologies & Therapies (a4tec) - Associação

Rui L Reis

Ana Rita Cruz Duarte

Jorge Manuel Nunes Correia Pinto

Rui Miguel Fernandes Duarte

The present disclosure relates to injectable and expandable compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely to fill and/or fuse a tissue defect. The present disclosure relates to compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely for bone tissue defect filling/fusion. The design of extendable and expandable compositions for bone fusion is one of the most challenging fields in the intersection of polymer and biomedical engineering. An aspect of the present disclosure relates to an injectable expandable composition for use in medicine, veterinary or cosmetic, comprising a polycaprolactone particle filler; a polydopamine adhesive bound to said filler; a polymethacrylic acid plasticizer bound to said polydopamine adhesive.

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Oporto, Portugal

Rui L Reis