Medtronic Minimed, Inc.

Medsolve Technologies, Inc.

Rudy Montalvo

Rajiv Shah

Bahar Reghabi

Yanan Zhang

Raymond P Feith

April A Marano-Ford

Susan McConnell-Montalvo

A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

Method of forming a molded protein matrix for a sensor

Molded protein material in form of pellet for sensor

A hypodermic syringe employing a plunger slidably disposed within a barrel. The plunger has a mounting hole extending through the seal end thereof to receive a mandrel. The mandrel has a flexible flange to be releasably engaged with the plunger. A spring element withdraws the mandrel into a cavity within the plunger upon full extension of the plunger within the barrel. The barrel includes a hub retainer at the forward end thereof and a needle hub retained therein the mandrel includes barbed tines with surfaces having axes of the conical surfaces that are displaced from one another such that movement of the tines toward one another also brings the axes closer. A catch associated with the back end of the spring element coupled with the mandrel at the other end cooperates with shoulders on smooth surfaces within the cavities to retain tension within the bungee. The hub retainer and the needle hub cooperate to insure that the needle hub is constrained to limited motion such that the mandrel will fully engage the needle hub.

Syringe with retractable needle assembly

Method of forming a molded protein matrix for use in a sensor

Sensor containing molded solidified protein

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Woodland Hills, CA, United States of America

Rudy Montalvo