Pharmachemie B.v.

Rudolph Willem

Marcel Gielen

Dick De Vos

Abdeslam Bouhdid

Dirk De Vos

Monique Biesemans

Abdelaziz El Khloufi

Martine Kemmer

Mohammad Boualam

Tin polyaalkanecarboxylates having the formula &lsqb;(R R Sn) O &rsqb; wherein R represents C -C alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P&equals;3, q&equals;1, r&equals;1, s&equals;) and t&equals;1, p&equals;2, q&equals;2, r&equals;1, s&equals;0, and t&equals;1, p&equals;2, q&equals;1, r&equals;2, s&equals;1 and t&equals;2, have anti-tumor activity.

Tin polyoxaalkanecarboxylates and compositions containing them

This invention provides novel Sn compounds, i.e. di-n.butyltindihydroxybenzoates, which exhibit excellent activities against varies tumors. This invention also provides pharmaceutical compositions which contain said novel Sn compounds in combination with a suitable carrier, in particular aqueous solutions which are suitable for injection.

Dibutyltin bis(dihydroxybenzoates) and compositions containing these

The invention relates to novel aromatic fluorine-containing organotin compounds of the formula {(F.sub.5 C.sub.6 RCO.sub.2 SnBu.sub.2).sub.2 O}.sub.2 and {(F.sub.5 C.sub.6 RCO.sub.2).sub.2 SnBu.sub.2 } wherein R is CH.sub.2, CH.dbd.CH or a single bond between the phenyl ring and the CO.sub.2 group, and Bu is a butyl group; as well as to anti-tumour compositions containing as an active ingredient one or more of these compounds.

Aromatic fluorine-containing organotin compounds and anti-tumour

The invention relates to anti-tumor compositions containing as an active ingredient one or more compounds of the formula

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Vilvoorde, Belgium

Rudolph Willem