Institute Fuer Diagnostik Forschung

Insitut F&uuml;r Diagnostikforschung Gmbh

Poly-an Gmbh

Rudolf Volkmer-Engert

Kai Licha

Wolfhard Semmler

Andreas Becker

Carsten Hessenius

Bertram Wiedenmann

Jens Schneider-Mergner

Mathias Ulbricht

Lothar Germeroth

Holger Wenschuh

The description herein includes cyanine dyes and analogs of the vaso-active intestinal peptide. These are useful to provide peptide-dye conjugates for use as contrast media in optical diagnoses.

Short-warp peptide-dye conjugate as contrast agent for optical diagnostic

The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical dignostic agents, and diagnostic agents that contain these compounds.

Short-chain peptide-dye conjugates as contrast media for optical diagnosis

The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material

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Berlin, Germany

Rudolf Volkmer-Engert