Dartmouth College

Rudolf Volkmer

Dean R Madden

Patrick R Cushing

Lars Vouilleme

Prisca Boisguérin

Prisca Boinguérin

A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis.

Therapy and kit for the prevention and treatment of cystic fibrosis

Combination therapy and kit for the prevention and treatment of cystic fibrosis

The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.

Compositions and methods for inhibiting the interaction between CFTR and CAL

Growing community of inventors

Nordwestuckermark, Germany

Rudolf Volkmer