Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Rudolf Soos

Istvan Szekely

Sandor Zoltan

Lajos T Nagy

Gyorgy Hidasi

Gabor Kovacs

Eva Somfai

Laszlo Pap

Sandor Botar

Bela Bertok

Agnes Hegedus

Tamas Szabolcsi

Jozsef Nemes

Antal Gajari

Erzsebet Radvany

Rezso Kolta

Laszlo Toke

Jozsef Rakoczi

Ferenc Faigl

Bela Koszegi

Miklos Szelestei

Laszlo Vidra

Gabor T Szabo

Antal Gajary

Istvan Bitter

Geza Toth

Marianna Lovasz Nee Gaspar

Elemer Fogassy

Maria Tary

Gyula Balogh

Marianna Lovasz, Nee Gaspar

Jozsef Muskovits

Ferenc Lindwurm

Tivadar Puskas

Istvan Schler

Istvan Szekeley

Jozsef Bozzay

Peter Bencsik

Elemer Foggassy

Andras Rappi

Iren Boros Neee Gundar

Marianne Lovasz Nee Gaspar

Joszef Dukai

A process is disclosed for preparing a synergistic, crystalline product consisting of solely enantiomer pair 1RCisS and 1SCisR and enantiomer pair 1RTransS and 1STransR of cypermethrin in a 3:7 to 5:5 crystalline mixture, which comprises the steps of: (a) epimerizing an oily melt or a saturated solution of enantiomer pair 1RCisS and 1SCisR and enantiomer pair 1RTransS and 1STransR in a ratio other than 3:7 to 5:5, or a mixture of enantiomer pair 1RCisS and 1SCisR, enantiomer pair 1RTransS and 1STransR together with enantiomer pair 1RCisR and 1SCisS and enantiomer pair 1RTransR and 1STransS, said saturated solution including a protic or apolar, aprotic inert organic solvent by treating said oily melt or saturated solution with an organic or inorganic base at a temperature of -15.degree. C. to 30.degree. C. to precipitate crystals consisting solely of the 1RCisS and 1SCisR and the 1RTransS and 1RTransR enantiomer pairs in a 3:7 to 5:5 weight ratio; (b) isolating the precipitated crystals consisting solely of the enantiomer pairs 1RCisS and 1SCisR and 1RTransS and 1STransR at -10.degree. to 30.degree. C., optionally after inoculating the reaction mixture with a seeding crystal consisting of a mixture of the enantiomer pairs 1RCisS and 1SCisR and 1RTransS and 1STransR at a weight ratio of 3:7 to 5:5 before crystallization; and (c) repeating any of the above steps, if necessary.

Insecticidal composition comprising more than one active ingredient

According to the present invention there is provided a synergistic insecticidal composition containing more than one active ingredients and being harmless to environment characterized by comprising in an amount of from 0.001 to 99% by weight a synthetic pyrethroid of the Formula /I/ ##STR1## namely substantially only the 1RtransS and 1StransR entantiomer-pair /Ib/ out from the possible eight isomers--optionally in admixture with an amount of up to 100% by weight of one or more activator/s/ and auxiliary agent/s/, particularly antioxidants, stabilizing agents, wetting agents, emulsifying agents, dispersing agents, antifoam agents, diluents and/or fillers. The enantiomer-pair Ib consisting of the 1RtransS and 1StransR isomers is new and the invention also relates to the said new enantiomer-pair and a process for the preparation thereof. The advantage of the insecticidal composition of the present invention is that it is less toxical towards warm-blooded animals and useful parasites and is therefore much less harmful to the environment.

The invention is directed to a new process for the preparation of carbinols of the general formula I ##STR1## by reaction chloral and olefins of the general formula ##STR2## and by optional acylation of the product comprising dissolving a catalyst of the general formula III

Process for the preparation of trichloromethyl carbinols

Process for separating pyethroid geometric isomers

The invention relates to a new process for separating the four stereoisomers of the cyclopropanecarboxylic acids of the formula ##STR1## wherein R stands for a methyl group or a halogen atom. The process comprises

Process for the separation of isomeric cyclopropane-carboxylic acids

The present invention relates to a process for the selective separation of esters of the general formula II

Process for the separation of esters

The invention relates to a process for the preparation of enantiomers of trans vinyl-cyclopropane carboxylic acids of the formula I, ##STR1## wherein R is a methyl group or chlorine atom, by resolution of racemic trans compound or mixture of racemic cis and trans compounds by using (+)- or (-)-N-(1-formamido-2,2,2-trichloroethyl)-piperazine as a resolving agent in a polar solvent then separating the crystallizing salt of (+)-trans carboxylic acid and (-)-resolving agent or (-)-trans carboxylic acid and (+)-resolving agent from the mother liquor by filtration and obtaining the enantiomers by acidifying the mother liquor or the salts suspended in water followed by extraction with a solvent and evaporation. The products so obtained may be used as starting materials for the preparation of insecticides.

Process for the preparation of optically active cyclopropane carboxylic

The invention relates to a new process for preparing unsaturated geminal dihalogen compounds. More particularly, the invention concerns a process for preparing compounds of the formula (I) ##STR1## wherein X is halogen,

Process for the preparation of unsaturated geminal dihalogen compounds

The invention relates to a new process for the preparation of cyclopropanecarboxylic acids of the formula (I) ##STR1## wherein X and Y independently stand for halogen, by the alkaline hydrolysis of the corresponding alkyl esters having 1 to 6 carbon atoms in the alkyl moiety, in or without a water-miscible organic solvent, in the presence of a phase transfer catalyst. The hydrolysis is carried out with a 2 to 50% by weight aqueous alkali hydroxide solution. If desired, under suitable conditions the cis/trans ratio of the original ester can be altered in the end products. The cyclopropanecarboxylic acids of the formula (I) are obtained in a high purity and are useful intermediates of insecticidally active pyrethroids.

Process for the preparation of dihalovinylcyclopropanecarboxylic acids

The invention concerns a new process for the preparation of polyhalogenphenyl carbamates of the formula (I)

Process for the preparation of polyhalogenphenyl carbamates

A process is disclosed for the preparation of an optically active or racemic cyclopropanecarboxylic acid of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is lower alkyl or halogen;

Preparation of cyclopropanecarboxylic acid esters

A method of making an insecticidal pyrethrin by oxidation in aprotic organic solvent. The compounds are of the formula: ##STR1## wherein R.sup.11 is straight or branched chain lower alkyl or 1-alkenyl or hydrogen;

Process for the preparation of pyrethrins and analogues thereof and

Insecticidal compounds of the formula: ##STR1## wherein R.sup.11 is a straight or branched chain lower alkyl or 1-alkenyl or hydrogen;

Chemical compounds

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Budapest, Hungary

Rudolf Soos