Hoechst Aktiengesellschaft

Rudolf Schneider

Hubert Mullner

Eugen Uhlmann

Peter Eckes

Bernadus Uijtewaal

Gunter Donn

Hubert M Ullner

G Unter Donn

A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.

Multifunctional RNA having self-processing activity, the preparation

Virus genes, such as coat protein genes, which confer viral resistance or bring about a reduction in the signs of infection by the corresponding virus can be combined with herbicide-resistance genes, such as the phosphinothricin resistance gene, for the transformation of plants. A combination of a viral gene and a herbicide-resistance gene facilitates the selection of transgenic plants. In addition, in practical field cultivation, the vitality of the plants is increased by the virus tolerance, and an improved plant protection is possible due to the herbicide resistance gene.

Virus/herbicide resistance genes, processes for producing same and their

A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof. Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.

Virus genes, for example coat protein genes, which bring about a reduction in the signs of infection by the corresponding virus or bring about virus resistance can be combined with herbicide-resistance genes for the transformation of plants. A combination of this type facilitates the selection of the transgenic plants. In addition, in practical field cultivation, the vitality of the plants is increased by the virus tolerance, and an improved plant protection is possible owing to the herbicide-resistance gene.

Transgenic plants displaying virus and phosphinothricin resistance

Expression of a multigene RNA having self-splicing activity An RNA is expressed which can release two or more active genes by means of inserted ribozyme structures. The expression can be carried out in plants or other organisms.

Growing community of inventors

Kelkheim/Taunus, Germany

Rudolf Schneider