Behringwerke Aktiengesellschaft

Hoechst Aktiengesellschaft

Behring Diagnostics Gmbh

Rudolf Schmidtberger

Ernold Granzer

Stefan Mullner

Wolfgang Kapmeyer

Burkhard Enders

Kurt Kesseler

Andreas Wiegand

Hans-Detlef Dopatka

Michael Noah

Wolfgang Ax

Detlef Schulze

Franz Porzsolt

Christoph Tautz

Dagmar Steuer

The present invention relates to a method for carrying out immunochemical reactions and to regenerable solid phases which can be used for this purpose. When use is made of precious metals, preferably gold, as the solid phase, and also of certain reducing agents or oxidizing agents, such as, for example, sodium borohydride and tetrabutylammonium hydroxide, with or without the addition of detergents, the solid phase can be employed repeatedly, following regeneration.

Regenerable solid phase for carrying out specific binding reactions

The invention relates to a pharmaceutical containing an effective amount of a polyhydroxymethylene containing grafted ethoxylated alcohols and/or ethoxylated carboxylic acids. The pharmaceutical is used for the treatment of dyslipoproteinemias.

Pharmaceuticals comprising polyhydroxymethylene derivatives, process for

Agents for immunochemical tests which contain polymers containing carboxyl groups and processes for carrying out such tests are described. These polymers are capable of improving the results obtained with such tests, in that they suppress non-specific reactions and increase the sensitivity of the tests.

Agent for immunochemical tests which contains polymers containing

A method for the determination of a partner in an immunochemical reaction, in which one of the partners, which is dissolved in an aqueous fluid, is allowed to react with the other partner, which is covalently bonded to a solid phase, which comprises allowing the reaction to take place in the presence of 0.1 to 3 g/100 g of the aqueous fluid of a surfactant of the formula I

Method for the nephelometric or turbidimetric determination of proteins

An agent for the determination of apolipoprotein B in blood, plasma or serum by an agglutination method, containing a dispersion of particles to which antibodies against Apo B are bound, as well as an agglutination method, are described.

Diagnostic agent and a method for the determination of apolipoprotein B

In the method for the evaluation of agglutination reactions between a reagent and a biological fluid to be examined, the reagent and the biological fluid are intimately mixed by agitation with a tumbling motion. The mixture is then placed in the ray path of an optical measuring system and, while maintaining the tumbling motion and superimposing a translational motion at right angles to the optical axis of the measuring system, an image of the agglutinates formed in the mixture is produced on a focusing screen, and the image is evaluated with an evaluation unit.

Method for the evaluation of agglutination reactions

Incubation media intended for solid-phase immunometric assays and containing lactoferrin are described. Compared with the media used hitherto, these incubation media have the advantage that they prevent, especially in the case where heated sample material is used in the assays, false results on determination of antigens or antibodies.

Lactoferrin-containing incubation medium for solid-phase immunometric

A process for reducing turbidity in a dried and redissolved control serum and a dried and reconstituted control serum with reduced turbidity are described. The process can also be applied to control sera for lipid determination, and in particular also to those with an increased lipid content.

Process for reducing turbidity in control sera

A process for binding and removing lipoproteins from aqueous fluids is described, the lipoproteins being bound to polyhydroxymethylene, onto which is grafted an oxyethylated alcohol or an oxyethylated carboxylic acid, and, where appropriate, being eluted from the polyhydroxymethylene. The process is also suitable for blood plasma or serum.

Process for removing lipoproteins using derivatized polyhydroxymethylene

The invention relates to modified immune globulins, a process for preparing them by treating immune globulins in a slightly acidic to neutral solution with a molar excess of a primary amine and a carbodiimide or salts thereof and pharmaceutical compositions containing modified immune globulins.

Amidated immune globulins and process for preparing them

An in vitro method for the diagnosis of immunization states which involves measuring, in an electric field, the changed mobility of charged indicator particles, other than macrophages, which particles have been treated with (1) a suspension of lymphocytes that have been incubated with an antigen or (2) the cell-free supernatant of such a suspension of incubated lymphocytes.

Growing community of inventors

Marburg, Germany

Rudolf Schmidtberger