Veb Arzneimittelwerk Dresden

Rudolf Schirutschke

Klaus Braun

Werner Grawert

Klaus-Dieter Volzke

Detlev Groger

Monika Muller

Christoph Dauth

Liselotte Hohne

Klaus Breuel

Eva Borowski

Gisela Nordmann

Dieter Erge

Edda Knothe

Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts.

Process for the fermentation production of ergoline derivatives

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Rudolf Schirutschke