Hoffmann-la Roche Inc.

Rudolf L Then

Synese Jolidon

Raffaello Masciadri

Dennis D Keith

Manfred Weigele

Henri Stalder

Ivan Kompis

Ka-kong Chan

Philippe Guerry

Harry A Albrecht

Substituted benzyl pyrimidines

Pharmaceutical preparations containing an antibacterially-active synergistic combination of epiroprim and dapsone are useful in the treatment or control of infections caused by mycobacteria, Actinomycetes and toxoplasmosis pathogens.

Antibiotic combination

There are presented anti-bacterial cephalosporins having broad antimicrobial activity of the formula ##STR1## wherein R.sub.1 is an antibiotically active quinolonyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkoxy, amino, lower alkylthio and amido; R.sub.3 is selected from the group consisting of hydrogen, and acyl group, and m is 0, 1 or 2 and the readily hydrolysable esters or salts of these compounds and hydrates of the compounds of formula I or of their esters or salts.

Anti-bacterial cephalosporin compounds

Growing community of inventors

Weil, Germany

Rudolf L Then