Spofa United Pharmaceutical Works

Rudolf Kotva

Miroslav Semonsky

Antonin Cerny

Jiri Krepelka

Karel Rezabek

Miroslav Seda

Marie Auskova

Vojtech Pujman

Hana Vesela, Deceased

Oskar Andrysek

A procedure is described for the preparation of a novel group of alkyl cyanomethyl ergoline-I derivatives and pharmaceutically acceptable salts thereof. The compounds are D-6-alkyl-8-cyanomethylergoline-I derivatives of the formula ##STR1## wherein R is an alkyl group of 2-4 carbon atoms.

Alkyl cyanomethyl ergoline-I derivatives and salts thereof, and methods

5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans.

Derivatives of carboxyalkyl imino- and thioxo-barbituric acids

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Prague, Czechia

Rudolf Kotva