Dr. Karl Thomae Gmbh

Boehringer Ingelheim Gmbh

Karl Thomae Gmbh

Boehringer Ingelheim Pharma Kg

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Other

Basf Aktiengesellschaft

Boehringer Ingelheim Kg

Boehringer Ingelheim Pharma Gmbh & Co Kg

Novo Nordisk A/s

Rudolf Hurnaus

Wolfgang Grell

Robert Sauter

Gerhart Griss

Manfred Reiffen

Eckhard Rupprecht

Bernhard Eisele

Walter Kobinger

Ludwig Pichler

Gerhart Griss, Deceased

Klaus Rudolf

Michael Mark

Roland Maier

Dirk Stenkamp

Eberhard Woitun

Joachim Mierau

Gunter Schingnitz

Gerhard Hallermayer

Joachim Kahling

Peter Muller

Ralph-Michael Budzinski

Nikolaus Kaubisch

Knud Erik Andersen

Stephan Georg Mueller

Bernd Peschke

Dieter Hinzen

Eckhart Bauer

Rudolf Bauer

Alexander Dreyer

Bernd Krist

Philipp Lustenberger

Kai Gerlach

Claus S Schneider

Kirsten Arndt

Peter Gruber

Marcus Schindler

Matyas Leitold

Florencio Zaragoza Dorwald

Peter Baruch Mueller

Wolfgang Steglich

Ulla Grove Sidelmann

Gebhard Adelgoss

Gebhard Schilcher

Bernard Eisele

Manfred Kleemann

Boerries Kuebel

Stephan Georg Muller

Henri Doods

Wolfgang Eberlein

Richard Reichl

Walter Haarmann

Ingrid Pettersson

Michael Entzeroth

Birgitte Langer Eriksen

Birgitte Schjellerup Wulff

Florencio Zaragoza Dörwald

Birgitte Eriksen

Tine Krogh Jørgensen

Eckhard Ruprecht

Stephan Georg Müller

The present invention relates to substituted piperidines of general formula wherein R, Rto R, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

The present invention relates to substituted piperidines of general formulawherein R, Rto R, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

The present invention relates to substituted piperidines of general formulawherein

Substituted piperidines, medicaments containing these compounds, and methods for the production thereof

Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula Iwherein R, R, R, R, R, R, A, X, Y and Z are as defined in the specification.

Substituted imidazoles, their preparation and use

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Imidazole compounds

Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis

Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors

Phenylacetic acid benzylamides having the following general structure

Phenylacetic acid benzylamides

The present application relates to the uses of phenylacetic acid benzylamides and new (S)(+)-2-ethoxy-4-[N-[1-2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbon ylmethyl]-benzoic acid and the salts thereof, which have valuable pharmacological properties, namely an effect on the intermediate metabolism, but particularly the effect of lowering blood sugar.

Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R.sup.1 and R.sup.2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between the denote 5- to 7-membered saturated, monocyclic or heterocyclic rings which may optionally also be interrupted by an oxygen or sulfur atom or by an imino group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote hydrogen or lower alkyl, R.sup.5 additionally denotes lower alkoxy, R.sup.7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl having up to 17 carbon atoms.

O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such

Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.

Substituted thiazoles and oxazoles and 2-hydroxy-morpholines

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula ##STR1## (wherein n, m, p, A, W.sup.1, W.sup.2, X, Y, and R.sup.1 to R.sup.11 are as defined in claim 1) and the isomers, isomer mixtures and salts thereof, which have useful properties, in particular an inhibitory effect on cholesterol biosynthesis.

Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their

The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R.sup.1 to R.sup.7 are defined as in claim 1, the isomers, isomer mixtures and salts thereof, which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis.

N,N-disubstituted arylcycloalkylamines, the salts thereof,

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Biberach, Germany

Rudolf Hurnaus