Bayer Aktiengesellschaft

Miles Inc.

Bayer Aktiengellschaft

Rudolf H Hanko

Stefan Wohlfeil

Martin Beuck

Stanislav Kazda

Johannes-Peter Stasch

Andreas Knorr

Peter Fey

Thomas Kramer

Walter Hubsch

Ulrich E Muller

Matthias Muller-Gliemann

Jurgen Dressel

Siegfried Zaiss

Ozkan Yalkinoglu

Hilmar Bischoff

Dirk Denzer

Claudia Hirth-Dietrich

Ulrich E M Uller

Matthias M uller-Gliemann

J Urgen Dressel

Mazen Es-Sayed

Trevor S Abram

Graham Sturton

Thomas Kr Amer

Walter H Ubsch

Ulrich Niewohner

Mary F Fitzgerald

Stephen Richard Tudhope

Gabriele Braunlich

Rudiger Fischer

Wendy J McDonald-Gibson

Siegfried Raddatz

Michael Matzke

Klaus Mohrs

Paul P Tamburini

Hanno Wild

Klaus-Helmut Mohrs

Hermann Wehlmann

David G Osterman

Richard D Connell

Michael E Katz

Heiner Apeler

Jurgen Beunink

Michael Dorschug

Stephan Schneider

Hans-Dietrich Horlein

Stanisiav Kazda

Walter Husch

Thomas Gould

Hans-Peter Belleman

Steve Tudhope

John-Edward Butler-Ransohoff

R Udiger Fischer

Gabriele Br Aunlich

Hans-Peter Bellemann

hIL-4 mutant proteins used as antagonists or partial agonists of human

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid

The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.

Heterocyclically substituted phenylacetic acid derivatives and their use

Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Substituted pyridines and 2-oxo-1,2-dihydropyridines

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterocyclylcarbonyl substituted benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives are prepared by reacting appropriately substituted hydroxybenzene butanoic acid esters with heterocyclic ketones. The inventive compounds can be used for the preparation of medicaments, particularly of medicaments for the treatment and prevention of acute and chronic inflammatory processes.

Heterocyclylcarbonyl substituted benzofuranyl- and

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating. The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives

6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the substituents. The compounds are useful for the treatment of actual and chronic inflammatory diseases, particularly of the airways and the gastro-intestinal tract.

Amino-benzofuryl-and thienyl-derivatives

Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.

Substituted biphenylpyridones

Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,

The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.

Substituted monopyridylmethyl derivatives

Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.

Phenylglycinamides of heterocyclically substitued phenylacetic acid

The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The inventive compounds are suitable for the prevention and treatment of acute and chronic inflammatory processes, particularly of the airways.

Oxalylamino-benzofuran- and benzothienyl-derivatives

Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.

Substituted 2,4-imidazolidinediones

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Essen, Germany

Rudolf H Hanko