Boehringer Ingelheim Kg

Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

C. H. Boehringer Sohn

Rudolf Bauer

Joachim Mierau

Rolf Banholzer

Gunter Schingnitz

Richard Reichl

Rudolf Hurnaus

Herbert Merz

Walter Kobinger

Claus S Schneider

Ludwig Pichler

Rainer Sobotta

Dieter Hinzen

Gerhart Griss, Deceased

Adolf Langbein

Hans Michael Jennewein

Helmut Wick

Werner Schulz

Alex Heusner

Esters of bi- and tricyclic amino alcohols, their preparation and their

Esters of bi- and tricyclic amino alcohols and their use in

Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and:

Esters of thienyl carboxylic acids and amino alcohols and their

3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

Certain 3-bromo-2,6-dimethoxybenzamides and pharmaceutical use thereof

Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.

Tetrahydrobenzothiazoles, and the preparation and use thereof

This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms, R.sub.2 represents a hydrogen atom or an alkyl group, R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms, R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

Tetrahydro-benzthiazoles, the preparation thereof and their use as

This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms.

This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynylk group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms,

The invention herein relates to novel quaternary 6,11-dihydro-dibenzo-[b,e]-thiepine-11-N-alkylnorscopine ethers, the preparation thereof, and their use as spasmolytics or bronchospasmolytics.

Quaternary 6,11-dihydro-dibenzo-[b,e]-thiepine-11-N-alkylnorscopine

Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.

8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof

Compounds of the formula ##STR1## wherein ONE OF R and R' is alkyl of 1 to 4 carbon atoms,

Quaternary N-.beta.-substituted N-alkyl-nortropine benzilates

Spray compositions, preferably in aerosol form, for inhalation therapy of bronchial disorders, especially acute or chronic asthma and acute or chronic obstructive bronchitis, containing as an active ingredient N-ethyl-norscopolamine methobromide or N-methyl-scopolammonium bromide optionally in combination with a mucolytic.

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Wiesbaden, Germany

Rudolf Bauer