Basilea Pharmaceutica Ag

Dsm IP Assets B.v.

Ruben Van Summeren

Daniel Mink

Mario Waser

Harrie Vaessen

Johan Franz Gradus Antonius Jansen

Paulus Lambertus Alsters

Engelina Catharina Kleuskens

The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.

Process for the manufacture of isavuconazole or ravuconazole

Use of a transition metal complex a) as a drier for air drying auto-oxidative resin composition comprising a polymer b) comprising unsaturated fatty acid residues, wherein the transition metal complex a) has a cation of the following structure (I) wherein R&#x2550;C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue; R&#x2550;H, C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms; X&#x2550;O, OC(R)O in which a=4 when X&#x2550;O, and a=3 when X&#x2550;OC(R)O, R&#x2550;C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue. 

Manganese complex drier for coating compositions

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Weert, Netherlands

Ruben Van Summeren