North Carolina State University

Other

Pathogen Removal and Diagnostic Technologies Inc.

The University of North Carolina at Chapel Hill

Bayer Corporation

Hoechst Celanese Corporation

Pathogen Removal and Diagnostics Technologies Inc.

Ruben Guillermo Carbonell

Peter K Kilpatrick

Joseph Desimone

Joseph M DeSimone

David John Hammond

Patrick Vasconcelos Gurgel

Brian J Novick

Nael Zaki

Julia Tait Lathrop

Larisa Cervenakova

Roberto Guzman

David J Hammond

Behnam Pourdeyhimi

Steven James Burton

Stefano Menegatti

Jonathan L Kendall

Florence E Henon

Honglue Shen

Li Ang Chen

Stephanie A Crette

James B McClain

Timothy J Romack

T Mark McCleskey

Eva Rachel Birnbaum

Richard H Guenther

William Tumas

George A Serad

George W Roberts

Joseph A Buettner

George A Baumbach

Yong Zheng

Juan L Torres

John M Lang

Kimberly R Powell

Johnny D Powers

Samana Roy Chowdhury

Matthew A Jones

Anup K Singh

Patrick D Bastek

Christopher L McAdams

Amith D Naik

Haiyan Liu

Steve A Lommel

Sara Honarbakhsh

Viterose Wiltshire-Lyerly

Nael Saki

Dawei Xu

Douglas J Kiserow

Haiou Yang

Viteros Wiltshire-Lyerly

Benjamin G Bobay

Michael Leonard Heller

Sumana Roy Chowdhury

David Hammond

The invention provides polymer-grafted and functionalized nonwoven membranes adapted for use in bioseparation processes, the membranes including a nonwoven web of polyester fibers having an average fiber diameter of less than about 1.5 microns, each of the plurality of polyester fibers having grafted thereon a plurality of polymer segments constructed of a methacrylate polymer, each polymer segment carrying a functional group adapted for binding to a target molecule. The invention also provides a method of bioseparation comprising passing a solution comprising the target molecule, such as a protein, through the nonwoven membrane of the invention such that at least a portion of the target molecule in the solution binds to the nonwoven membrane. A method for preparing a polymer-grafted and functionalized nonwoven membrane adapted for use in bioseparation processes is also provided.

Grafted islands-in-the-sea nonwoven for high capacity ion exchange bioseparation

This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.

Protease-resistant peptide ligands

Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.

Prion protein ligands and methods of use

This invention is directed to the production of improved chromatographic resins and method of making and using such resins.

Alkaline-stable chromatographic resins

The present invention describes a novel process for the conformal coating of polymer fibers of nonwoven substrates. This process is based on modification of polymer fiber surfaces by controlling the degree of etching and oxidation to improve adhesion of initiators to the surface and to facilitate subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increased hydrophilicity, attached ligands or changed surface energy. The invention includes the modified polymer fibers produced by the process described herein.

Conformal coating of polymer fibers on nonwoven substrates

A biodegradable delivery system for actives such as pharmaceutical drugs. The delivery system includes actives infused into the capsid of a purified plant virus. The loaded capsids are embedding in electrospun biodegradable polymer fibers, forming a nonwoven fabric.

Biodegradable non-woven fabric having plant virus encapsulated actives for drug delivery

Environmentally friendly solvents used to dissolve or remove residues and/or substances from substrates wherein the residue and/or substance is contacted with a Generally Recognized As Safe solvent to dissolve the residue and/or substance in the solvent followed by the extraction of the residue and/or substance from the solvent such as by contact with carbon dioxide.

Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents

The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 &#x3bc;m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.

Devices and methods for removing target agents from a sample

Particles embedded in a porous substrate for removing target analyte from a sample

A method of deresinating a crude oil comprises contacting the crude oil with a carbon dioxide containing fluid, the crude oil having an initial API gravity and comprising an oil phase, resins, and asphaltenes, and wherein the carbon dioxide containing fluid enters the oil phase of the crude oil in a manner such that the resins and asphaltenes precipitate out of the crude oil such that the final API gravity of the crude oil is higher than the initial API gravity of the crude oil.

Methods of deresinating crude oils using carbon dioxide

Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

Prion protein binding materials and methods of use

Growing community of inventors

Raleigh, NC, United States of America

Ruben Guillermo Carbonell