Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Ruben Alvarez Sanchez

Bernd Kuhn

Jens-Uwe Peters

Alexander Flohr

Konrad H Bleicher

Markus Rudolph

Matthias Koerner

Hans Hilpert

Uwe Grether

Luca Claudio Gobbi

Jean-Marc Plancher

Katrin Groebke Zbinden

Wolfgang Haap

Simona Maria Ceccarelli

Holger Kuehne

David Banner

Harald Mauser

Guido Hartmann

Daniela Alberati

Katrin Groebke Zbinzen

Peter Hartman

The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R, Rand Rare as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

Imidazopyrimidine derivatives

The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R, R, R, R, Rand A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.

Imidazopyridines

The invention relates to a compound of formula (I) wherein Aand Rto Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Cyclopentane derivatives

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Rosenau, France

Ruben Alvarez Sanchez