Pharmacia & Upjohn Company

Pharmacia Corporation

Royal J Haskell

Tugrul T Kararli

Subhash Desai

Michael J Hageman

Mark Kontny

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a therapeutically effective amount, wherein the drug is present in the form of solid particle, about 25% to 100% by weight of which are smaller than 1 &#x3bc;m. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders and have particular advantages where rapid onset of therapeutic effect is desired.

Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect

There is provided a process for reducing particle size of a drug, the process comprising (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 &mgr;m; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.

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Kalamazoo, MI, United States of America

Royal J Haskell