Redpoint Bio Corporation

Roy Kyle Palmer

Robert Bryant

Rok Cerne

Ivona Bakaj

Karnail S Atwal

F Raymond Salemme

S Paul Lee

M N Tulu Buber

Daniel J Long

Francis Xavier Brennan

Dennis Sprous

Anita B Atwal, Legal Representative

The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.

Rebaudioside C and its stereoisomers as natural product sweetness enhancers

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel

The present invention is directed to the use of a compound of Formula I and physiologically acceptable salts thereof wherein G, G, G, R, R, R, R, R, and Rare defined herein. Compounds according to Formula I can be used to enhance a sweet taste produced by a tastant. The invention is also directed to compositions comprising a compound according to the above formula. Other aspects of the invention provide methods, compounds, and compositions for improved food products wherein the food product comprises a compound according to Formula I and a reduced amount of a sweet tastant.

Heterocyclic compounds as sweetener enhancers

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Cranbury, NJ, United States of America

Roy Kyle Palmer