Institut Pasteur

Roxane Simeone

Roland Brosch

Laleh Majlessi

Nadine Honore

Fadel Sayes

Matthias Groschel

Recombinant strains ofbacille Calmette-Guerin (BCG) comprising a heterologous nucleic acid sequence of() are provided. In some embodiments the heterologous nucleic acid sequence ofcomprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the() proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to theproteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to theproteins MMAR5429, MMAR5430, MMAR5431, MMAR5432, MMAR5433, MMAR5434, MMAR5435, MMAR5436, MMAR5437, MMAR5438, MMAR5439, MMAR5440, MMAR5441, MMAR5442, MMAR5454, MMAR5456, MMAR5458, MMAR5459, MMAR5460, and MMAR5461. Pharmaceutical compositions, kits, methods of inducing an immune response againstin a subject, and methods of treating aninfection in a subject are also provided, among other things.

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Paris, France

Roxane Simeone