W. R. Grace Co.

W. R. Grace Co.-conn.

Rowena L Roberts

Akiva T Gross

Alan B Chmurny

Robert J Kupper

Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

Process for preparing as partyl-phenylalanine dipeptides

Aspartyl-beta substituted phenylalanine dipeptides

Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.

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Derwood, MD, United States of America

Rowena L Roberts