Merck + Co., Inc.

Rowena D Ruzek

Linghang Zhuang

Melissa S Egbertson

John S Wai

David Askin

Ulf H Dolling

Philip J Pye

R Scott Hoerrner

Debra S Perlow

Mark Cameron

Wei Han

Remy Angelaud

Danny Mancheno

Bruce S Foster

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. 

HIV integrase inhibitors

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North Wales, PA, United States of America

Rowena D Ruzek