Cyanagen S.r.l.

Rossana Perciaccante

Leopoldo Della Ciana

Thomas Paul Jansen

Federica Rodeghiero

Johannes Pill

Norbert Gretz

Lorenzo Biagini

Zeneida Herrera Pérez

Jiaguo Huang

Stefanie Weinfurter

Stefania Geraci

Manuela Vargiolu

Marina Eleonora Vettraino

Giacomo Rodeghiero

Dario Foglietta

Tiziana Picascia

Srishti Vajpayee

Della Ciana Leopoldo Leopoldo

A method for increasing the light emission produced by the chemiluminescent reaction of 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione, a peroxidase enzyme or a conjugate thereof, an enhancer, a co-enhancer and a peroxide oxidizer, wherein the enhancer is an anionic N-alkylphenothiazine and the co-enhancer is selected from a 4-dialkylaminopyridine or an N-azole, and

Ultra-sensitive chemiluminescent substrates for peroxidase

A kit for performing an assay for determining an analyte in a sample with an extended shelf-life, wherein the kit comprises a chemiluminescent cyclic dihydrazide, an enhancer, a co-enhancer, and a peroxide oxidizer. The kit is useful in blot assays and immunoassays for the detection of proteins and nucleic acid molecules.

Chemiluminescent substrates for peroxidase with extended shelf-life

The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.

Tricarbocyanine-cyclodextrin(s) conjugates and use thereof

The present invention describes novel 7-alkylamino-3-(thienyl) coumarin fluorescent dyes of formula (I)  These dyes are water soluble, can be excited by the 405 nm excitation source and exhibit a large Stokes shift (&#x2265;80 nm). Furthermore, the dyes possess a reactive group for the labeling of biomolecules or other analytes.

Coumarin dyes and conjugates thereof

Method for increasing and regulating the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and an electron mediator (primary enhancer) through the use of an acylation catalyst (secondary enhancer) belonging to the class of N-azoles, i.e., a class of five-membered nitrogen heteroaromatic ring compounds containing at least one other atom of nitrogen. N-azoles, which are especially useful as secondary enhancers are imidazole, 1-methylimidazole, 1,2,3-triazole and 1,2,4-triazole. The invention also describes the use in diagnostic assays of chemiluminescent substrates containing said N-azoles, as secondary enhancers.

Method for increasing and regulating light emission from a chemiluminescent reaction

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Granarolo dell'Emilia, Italy

Rossana Perciaccante