United States Surgical Corporation

Other

Ross R Muth

Donald S Kaplan

Matthew E Hermes

John J Kennedy

Nagabhushanam Totakura

David L Brown

Henry A Holzwarth

Cheng-Kung Liu

Herbert W Korthoff

Roy D Gravener

John Matthew Kennedy

Steven L Bennett

Daniel Shichman

Richard N Granger

George R Proto

Keith Raymond D'Alessio

Charles E Gorman, Jr

Corbett W Stone

Mark S Roby

Ilya S Koyfman

Michael P Chesterfield

Ellen M Golds

Matthew E Hain

Darel L Gustafson

Robert D Torgerson

Darren E Zinner

Elliot A Gruskin

Synthetic absorbable sutures are filled with a stabilizing agent, preferably a mixture of glycerol and calcium lactate, and inserted into a retainer having a narrow convoluted passageway. The retainer is inserted into an open foil pouch with a package stabilizing element such as a paper sheet filled with stabilizing agent. The package containing the suture, retainer and package stabilizing element is sterilized, aerated, equilibrated to a relatively high moisture level, and sealed. Long lengths of suture and doubled-over and tripled-over suture may be withdrawn from the retainer with low force without damaging the suture. Bends and kinks in the suture are prevented so as to provide a synthetic absorbable suture having highly desirable out of package hand and feel. The suture an removed from the package exhibits improved tissue drag characteristics.

Packaged synthetic absorbable surgical elements

Polymer blends of glycolide and/or lactide homopolymer and/or glycolide/lactide copolymer and polycaprolactone and/or polytrimethylene carbonate homopolymer or copolymers thereof and absorbable surgical devices manufactured therefrom having improved mechanical properties, such as improved impact resistance and improved cyclic flex, are disclosed.

Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorabable surgical devices made therefrom

A method for removing residual xylene from sutures includes contacting the suture with water either subjecting the suture to an atmosphere containing water vapor or be immersing the suture in liquid water, followed by drying the suture.

Residual xylene removal from sutures

Surgical adhesion barriers and methods of using such surgical adhesion barriers are provided. Surgical adhesion barriers according to the present invention have at least one layer of a bioabsorbable material comprising copolymers and/or block copolymers derived from trimethylene carbonate. Alternatively, a multilayer surgical structure having one or more bioabsorbable layers superimposed on a non-absorbable layer is useful for minimizing or preventing formation of fibrous adhesions between a healing trauma site and adjacent surrounding tissue. Alternatively, a bioabsorbable non-woven fabric in adherent contact with at least one bioabsorbable layer of foam, film, mesh, web or woven fabric is also provided. One or more medicinal agents may be interposed between or disposed within any of the aforementioned layers.

Post-surgical anti-adhesion device

A completely bioabsorbable reinforced composite material for use in medical implants and a method for making same. The composite material comprises a hybrid yarn of intimately co-mingled reinforcement fibers of a crystalline polymer and matrix fibers of a polymer having a glass transition temperature below the melting point of the crystalline polymer. The hybrid yarn is heated under pressure to a processing temperature between the glass transition temperature of the matrix fibers and the melting point of the crystalline polymer to form a continuous matrix with reinforcing fibers of crystalline polymer. The composite material may be formed by a two step consolidation process.

Bioabsorbable medical implants

Methods for preventing and/or eliminating fogging of endoscope lenses during an endoscopic procedure which include the steps of introducing an endoscope into a body cavity and contacting the endoscope lens with a biocompatible and biodegradable composition containing a polyalkylene oxide while the lens is positioned within the body. Alternatively, the endoscope may be coated with a biocompatible polyHEMA coating which is activated by a biocompatible solution, such as water or saline, which may be introduced during use through a fluid conduit on the endoscope. Devices for preventing and/or eliminating fogging of endoscope lenses during endoscopic procedures and conveying antifogging solutions to the distal end of the endoscope are also provided, and may include a distensible applicator.

Compositions, methods and apparatus for inhibiting fogging of endoscope

A block copolymer for use in the fabrication of bioabsorbable articles such as monofilament surgical sutures is prepared by copolymerizing one or more hard phase forming monomers and 1,4-dioxan-2-one, and then polymerizing one or more hard phase forming monomers with the dioxanone-containing copolymer.

Absorbable composition

A method is provided for improving the in vivo strength retention of a bioabsorbable implantable medical device such as a suture.

Method for improving the in vivo strength retention of a bioabsorbable

Polymer blends of glycolide and/or lactide homopolymer and/or glycolide/lactide copolymer and polycaprolactone and/or polytrimethylene carbonate homopolymer or copolymers thereof and absorbable surgical devices manufactured therefrom having improved mechanical properties, such as improved impact resistance and improved cyclic flex, are disclosed. The blends may be prepared by polymerizing a glycolide or lactide containing polymer in the presence of a polymer derived from trimethylene carbonate or .epsilon.-caprolactone.

Blends of glycolide and/or lactide polymers and caprolactone and/or

A method for forming a surgical clip and fixture for use therein includes molding a polymeric clip body, the clip body having hinged legs, the polymer of the clip body being substantially amorphous. The clip body can then be moved to a desired configuration while being subjected to a temperature above the glass transition temperature. The molded clip body is then heated to a temperature within the crystallization range for a period of time sufficient to impart at least 20% crystallinity thereto to impart a spring back property. Also disclosed herein is a fixture for forming a surgical clip in accordance with this method.

Forming latchless surgical clip and fixture for use therein

A human growth factor (HGF), a human growth factor-containing composition or a medical or surgical device such as a wound dressing or suture filled with a human growth factor-containing composition is sterilized employing an ethylene oxide gaseous sterilizant.

Sterilization of growth factors

Synthetic absorbable sutures are filled with a stabilizing agent, preferably a mixture of glycerol and calcium lactate, and inserted into a retainer having a narrow convoluted passageway. The retainer is inserted into an open foil pouch with a package stabilizing element, such as a paper sheet filled with stabilizing agent. The package containing the suture, retainer and package stabilizing element is sterilized, aerated, equilibrated to a relatively high moisture level, and sealed. Long lengths of suture and doubled-over and tripled-over suture may be withdrawn from the retainer with low force without damaging the suture. Bends and kinks in the suture are prevented so as to provide a synthetic absorbable suture having highly desirable out of package hand and feel. The suture as removed from the package exhibits improved tissue drag characteristics.

A siliconized surgical needle is provided which requires significantly less force to effect tissue penetration than a standard siliconized needle.

Siliconized surgical needle and method for its manufacture

An absorbable composition useful for treating absorbable surgical devices to render the same storage stable and/or to enhance delivery of the article and/or a medico-surgically useful substance to a wound. The preferred composition includes collagen or a derivative thereof, a plasticizer and a surfactant.

Growing community of inventors

Brookfield, CT, United States of America

Ross R Muth