3m Innovative Properties Company

University of Colorado

Dartmouth College

Minnesota Mining and Manufacturing Company

Ross M Kedl

Randolph J Noelle

Cory L Ahonen

Catherine Haluszczak

Phillip J Sanchez

Paul D Wightman

George W Griesgraber

Mark A Tomai

Richard L Miller

James T Wolter

Albert E Seaver

William R Berggren

Isidro Angelo E Zarraga

James D Stoesz

Eugene E Harkins

Daniel R Danielson

Ronnie Ortiz

Isidro Angelo Eleazar Zarraga

A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.

Nucleic acid construct encoding an agonistic anti-CD40 antibody and a type I interferon

The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.

Immunostimulatory combinations

Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.

Methods and compositions for enhancing immune response

Immunotherapy comprising TLR9 ligand and CD40 ligand

Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody

Delivery of one or more immune response modifiers (IRMs) across a biological barrier by the use of a microneedle device.

Delivery of immune response modifier compounds

Ex vivo uses of immunostimulatory combinations

TLR9 agonist and CD40 agonist immunostimulatory combinations

The present invention provides immunostimulatory compositions that include an immune response modifier portion paired with an antigenic portion.

Immunostimulatory compositions and methods of stimulating an immune response

An electrospray coating head system for applying thin coating to a substrate comprising a slot or blade to meter a liquid onto a shaping structure which forces the liquid to have a single continuous and substantially constant radius of curvature around the shaping structure. A voltage applied to the liquid around the shaping structure causes the liquid to produce a series of filaments which are spatially and temporally fixed, the number of filaments being defined by a simple adjustment in the applied voltage. The filaments break up into a uniform mist of charge droplets and are driven to a substrate by electric fields to produce a coating. Also a method for electrospray coating wherein liquid to be coated is dispensed from a metering portion to a lower shaping means where it achieves a single continuous and substantially constant radius of curvature, a voltage is applied to produce a series of filaments of the liquid which are spatially and temporally fixed, and the filaments break up into a uniform mist of charge droplets.

Electrospray coating apparatus and process utilizing precise control of

Growing community of inventors

Roseville, MN, United States of America

Ross M Kedl