Imperial Chemical Industries Limited

Ici Americas, Inc.

Ross L Stein

Diane A Trainor

Anand Swaroop Dutta

Richard A Wildonger

Mitchell Glass

Joseph C Williams

There is provided a novel therapeutic agent for use in the prevention or treatment of adult respiratory distress syndrome and for use in the manufacture of a medicament for the prevention or treatment of adult respiratory distress syndrome, as well as a method of prevention or treatment of adult respiratory distress syndrome with the therapeutic agent and a method of treatment of cystic fibrosis with the therapeutic agent in combination with one or more other agents indicated for the treatment of adult respiratory distress syndrome.

Therapeutic agent for the prevention or treatment of adult respiratory

Proline derivatives

Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.

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Wilmington, DE, United States of America

Ross L Stein