The Mclean Hospital Corporation

Other

Northeastern University

Ross J Baldessarini

John L Neumeyer

Alexander S Campbell

Kehong Zhang

Frank I Tarazi

The invention features derivatives of R(&#x2212;)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.

R(&#x2212;)-11-hydroxyaporphine derivatives and uses thereof

The invention features derivatives of R(&#x2014;)-11-hydroxyaporphines and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.

R(&#x2014;)-11-hydroxyaporphine derivatives and uses thereof

A method of inhibiting motor hyperactivity in a mammal exhibiting the symptoms of attention deficit-hyperactivity disorder (ADHD) includes administering to a mammal a dopamine D receptor-selective antagonist.

Dopamine D4 receptor antagonists as treatment for attention deficit-hyperactivity disorder

This invention provides methods of effecting dopamine inhibition in a mammal by administering to the mammal l-threo-MPH which is substantially free from d-threo-MPH. Also provided by the invention are methods of inhibiting the effects of a stimulant in a mammal by administering to the mammal l-threo-MPH which is substantially free from d-threo-MPH.

Method of dopamine inhibition using l-threo-methylphenidate

Antidopaminergic agents having selective limbic activity, comprising (S)-enantiomers of aporphine compounds of either the following structures: ##STR1## wherein R.sub.1 is lower alkyl, alkyl substituted lower alkyl, alkyl substituted cycloalkyl, lower alkenyl, alkyl substituted lower alkenyl, lower alkynyl, alkyl substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl, and phenyl lower alkynyl, and the following structure where R.sub.1 is above and R.sub.2 and R.sub.3 are hydrogen, methyl, or R.sub.1 ##STR2## R.sub.1 is as above R.sub.4 is H, CH.sub.3 lower alkyl, or R.sup.1 C0--where R.sup.1 =CH.sub.3 or lower alkyl.

Growing community of inventors

Newton, MA, United States of America

Ross J Baldessarini