Piramal Critical Care, Inc.

Minrad Inc.

Medeva Pharmaceuticals Pa, Inc.

Ross C Terrell

John C McNeirney

William H Burns, Jr

Charles W Young

Joshua A Levinson

John C Mcneirney

Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties. The instant invention focuses on the dosage level where analgesia occurs but amnesia or lack of consciousness does not. In addition to identifying the dosage level where pain is sharply reduced or eliminated but awareness remains, a delivery system for safe and effective delivery of the agent is described.

Drug delivery system for conscious sedation

A method for the preparation of (CF)CHOCHF (Sevoflurane) is presented, which comprises providing a mixture of (CF)CHOCHCl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF)CHOCHF.

Method for the preparation of sevoflurane

A method for the preparation of sevoflurane which comprises (a) providing a liquid mixture of (CF)CHOCHCl, hydrogen fluoride, and an amine and (b) reacting the mixture, to form (CF)CHOCHF.

A method for the preparation of sevoflurane which comprises (a) providing a liquid mixture of (CF.sub.3).sub.2 CHOCH.sub.2 Cl, hydrogen fluoride, and an amine and (b) reacting the mixture, to form (CF.sub.3).sub.2 CHOCH.sub.2 F.

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Phillipsburg, NJ, United States of America

Ross C Terrell